Typhoid fever, caused by *Salmonella Typhi*, is a serious disease spread through contaminated food and water.

Recent studies showcase a troubling trend: *S. Typhi* is becoming increasingly resistant to antibiotics.

Countries like Pakistan, Bangladesh, and Nepal report high rates of drug-resistant typhoid. In Pakistan, about 64% of *S. Typhi* isolates are extensively drug-resistant, raising alarms about treatment options and public health safety.

*S. Typhi* is rapidly evolving, developing mutations that resist previously effective antibiotics. With limited options left, effective surveillance and improved sanitation practices are essential to control the spread of this dangerous infection.

Health authorities are prioritizing vaccine development as a strategy against drug-resistant typhoid. Typhoid conjugate vaccines are already showing promise in reducing cases, especially in vulnerable populations like children.

To combat antibiotic resistance, a multifaceted approach is crucial. This includes boosting global cooperation, improving vaccination efforts, and responsible antibiotic usage to protect public health and counter rising typhoid threats.

Addressing antibiotic-resistant typhoid fever is critical for public health. Future efforts must focus on enhancing health infrastructure and encouraging innovative solutions in antibiotic and vaccine development for better disease control.