A groundbreaking review from *Dove Medical Press* reveals that *P. gingivalis*, a bacterium linked to gum disease, significantly contributes to Alzheimer’s progression.

Chronic gum disease is associated with a 70% higher risk of Alzheimer’s. The harmful effects of *P. gingivalis* breach the blood-brain barrier, leading to neuroinflammation and neuron death, which are central to Alzheimer's pathology.

*P. gingivalis* produces gingipains that disrupt normal tau proteins and promote amyloid plaque formation. Animal studies indicate that infected mice exhibit Alzheimer-like symptoms, supporting the bacterium's role in disease progression.

With nearly 47% of adults suffering from gum disease in the U.S., better dental care could help reduce Alzheimer's risk. Targeted therapies and increased awareness about oral health might shift our approach to neurodegenerative diseases.

Despite strong evidence, some question whether *P. gingivalis* directly causes Alzheimer's. Critics suggest that its presence may be due to other factors, raising concerns about the complexity of Alzheimer's disease etiology.

Innovative strategies like periodontal screenings and vaccines targeting *P. gingivalis* could greatly impact Alzheimer's prevention. Additionally, emerging diagnostic tools may provide early detection opportunities, changing patient care.

The insights from the review highlight the need for collaboration across disciplines. By integrating dental health into Alzheimer's care, we may find new therapies that better address this devastating disease.