Ulcerative colitis (UC) is a chronic inflammatory bowel disease affecting the large intestine. It causes symptoms like abdominal pain and severe diarrhea.

Recent studies indicate that appendectomy, or appendix removal, may reduce UC relapse rates by 35%.

Traditionally, appendectomy was only performed for appendicitis.

Previous studies have shown a mixed bag regarding appendectomy's effects.

Experts believe the appendix plays an immune role in UC. Its removal may decrease harmful immune responses, leading to milder disease and fewer relapses. Animal studies support this theory, showcasing a decrease in colitis after appendix removal.

As research progresses, clinical trials are emerging to evaluate appendectomy's effectiveness in UC treatment.

The timing of appendectomy is critical; prior surgery may confer benefits, while post-diagnosis could pose risks. Ongoing research is essential to validate its safety and effectiveness as a treatment, ensuring patients receive the best care possible.